Reid K, Grundy D, Khan M I, Read N W
Department of Biomedical Science, University of Sheffield, UK.
Eur J Gastroenterol Hepatol. 1995 Feb;7(2):103-8.
To examine the hypothesis that nausea during vection arises directly from an underlying alteration in gastric motility.
The simultaneous application of vection and assessment of gastric emptying of a liquid, non-nutrient test meal allowed the examination of the interaction between changes in gastric motility and symptoms.
Studies were conducted in 14 volunteers. Vection was induced by seating the subject inside a rotating circular drum, which was painted with vertical black and white stripes. In the control study (n = 8) the drum was not rotated. Gastric emptying was measured by gamma scintigraphy of a radiolabelled isosmotic saline test meal.
Vection induced upper abdominal sensations (epigastric awareness) in 10 subjects, eight of whom subsequently reported nausea; autonomic symptoms of sweating and pallor were experienced by 12 subjects. Two subjects remained completely asymptomatic during vection. None of the subjects experienced any sensations during the control study. Gastric emptying was significantly delayed during vection (P < 0.01). There was a highly significant correlation between gastric emptying and the intensity of nausea. However, examination of the gastric emptying profiles did not support any direct association between altered gastrointestinal motor activity and symptoms. Two subjects with slowing of gastric emptying exhibited no nausea or upper abdominal symptoms, while another two experienced nausea when the underlying rate of gastric emptying was similar to that of the control period.
The delay in gastric emptying of a liquid test meal induced by vection appears to be a variable epiphenomenon of nausea. A cause and effect relationship between gastric emptying and nausea therefore appears unlikely.
检验关于运动病诱发的恶心直接源于胃动力潜在改变这一假设。
同时施加运动病刺激并评估液体非营养测试餐的胃排空情况，以研究胃动力变化与症状之间的相互作用。
对14名志愿者进行研究。让受试者坐在一个涂有黑白垂直条纹的旋转圆筒内诱发运动病。在对照研究（n = 8）中，圆筒不旋转。通过放射性核素闪烁扫描法测量放射性标记等渗盐水测试餐的胃排空情况。
运动病使10名受试者产生上腹部感觉（上腹部感知），其中8名随后报告有恶心；12名受试者出现出汗和面色苍白等自主神经症状。两名受试者在运动病期间完全无症状。对照研究期间所有受试者均无任何感觉。运动病期间胃排空显著延迟（P < 0.01）。胃排空与恶心强度之间存在高度显著相关性。然而，对胃排空曲线的检查不支持胃肠道运动活动改变与症状之间存在任何直接关联。两名胃排空减慢的受试者未出现恶心或上腹部症状，而另外两名在基础胃排空率与对照期相似时出现恶心。
运动病诱发的液体测试餐胃排空延迟似乎是恶心的一种可变附带现象。因此，胃排空与恶心之间的因果关系似乎不太可能。
