Mouchiroud D, Gautier C, Bernardi G
Laboratoire de Biométrie, Génétique et Biologie des Populations, U.R.A. 243, Université Claude Bernard, Villeurbanne, France.
J Mol Evol. 1995 Jan;40(1):107-13. doi: 10.1007/BF00166602.
The frequencies of synonymous substitutions of mammalian genes cover a much wider range than previously thought. We report here that the different frequencies found in homologous genes from a given mammalian pair are correlated with those in the same homologous genes from a different mammalian pair. This indicates that the frequencies of synonymous substitutions are gene-specific (as are the frequencies of nonsynonymous substitutions), or, in other words, that "fast" and "slow" genes in one mammal are fast and slow, respectively, in any other one. Moreover, the frequencies of synonymous substitutions are correlated with the frequencies of nonsynonymous substitution in the same genes.
哺乳动物基因同义替换的频率范围比之前认为的要广泛得多。我们在此报告，在给定哺乳动物对的同源基因中发现的不同频率与来自不同哺乳动物对的相同同源基因中的频率相关。这表明同义替换的频率是基因特异性的（非同义替换的频率也是如此），或者换句话说，一种哺乳动物中的“快”基因和“慢”基因在任何其他哺乳动物中分别也是快基因和慢基因。此外，同义替换的频率与同一基因中的非同义替换频率相关。
