Franzén L, Henriksson R, Littbrand B, Zackrisson B
Department of Oncology, Umeå University, Sweden.
Acta Oncol. 1995;34(2):219-23. doi: 10.3109/02841869509093959.
Radiotherapy of head and neck malignancies is accompanied by oral discomforts, such as epithelitis, pain and functional impairment. This can lead to chronic sequalae with subjective distress such as loss of taste and xerostomia and pronounced decrease in quality of life. Thus, the need to reduce the mucosal damage following radiotherapy is obvious. Therefore, we investigated the possible ability of sucralfate, an aluminium hydroxide complex of sulphated sucrose used in the treatment of gastric ulcer, in preventing oral discomfort in patients treated with curative intent for malignancies in the head and neck region. The study was double-blind, placebo-controlled and randomized and included 50 consecutive patients. The study demonstrated that the proportion of patients with severe mucosal reactions was significantly lower in the sucralfate group than in the placebo group.
头颈部恶性肿瘤的放射治疗会伴有口腔不适，如上皮炎、疼痛和功能障碍。这可能导致慢性后遗症，并伴有味觉丧失和口干等主观痛苦，生活质量明显下降。因此，减少放疗后黏膜损伤的必要性显而易见。为此，我们研究了硫糖铝（一种用于治疗胃溃疡的硫酸化蔗糖氢氧化铝复合物）预防头颈部恶性肿瘤根治性治疗患者口腔不适的潜在能力。该研究为双盲、安慰剂对照且随机分组，纳入了50例连续患者。研究表明，硫糖铝组严重黏膜反应患者的比例显著低于安慰剂组。
