Rheumatic manifestations of disorders of the central and peripheral nervous system.

Many inflammatory rheumatic conditions may result, in part, from local release of sensory neuropeptides; substance P is currently the best studied of these. Various neurologic diseases that result in movement disorders continue to come to the attention of rheumatologists, primarily because of the pain and stiffness associated with them, and they are often misdiagnosed. Neuroarthropathies remain the most distinctive of the joint disorders that appear to result directly from neurologic injury, but little new information concerning these disorders has been generated in the past year.