使用电子显微镜评估抗生素疗效：胍基脲基头孢菌素、BL-P1654和羧苄青霉素对大肠杆菌的形态学影响。
Evaluation of antibiotic efficacy using electron microscopy: morphological effects of guanylureido cephalosporin, BL-P1654, and carbenicillin on Escherichia coli.
作者信息
Ellis L F, Herron D K, Preston D A, Simmons L K, Schlegel R A
出版信息
Antimicrob Agents Chemother. 1976 Feb;9(2):343-6. doi: 10.1128/AAC.9.2.343.
Abstract
Early response of Escherichia coli to minimal inhibitory concentrations of 112883, BL-P1654, and carbenicillin was determined by [(14)C]leucine uptake and scanning electron microscopy morphology studies. [(14)C]leucine uptake was inhibited later by carbenicillin than by BL-P1654 or 112883. Cellular swelling at 30 min, septal region swelling, and lysis were the progressive morphological changes with BL-P1654 and 112883. Carbenicillin-treated cells showed septal region swelling, beaded chains, and lysis.
摘要
通过[¹⁴C]亮氨酸摄取和扫描电子显微镜形态学研究，确定了大肠杆菌对112883、BL-P1654和羧苄青霉素最低抑菌浓度的早期反应。与BL-P1654或112883相比，羧苄青霉素对[¹⁴C]亮氨酸摄取的抑制作用出现得更晚。用BL-P1654和112883处理后，细胞在30分钟时出现肿胀、隔膜区域肿胀和裂解等渐进性形态变化。用羧苄青霉素处理的细胞表现出隔膜区域肿胀、串珠状链和裂解。
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Evaluation of antibiotic efficacy using electron microscopy: morphological effects of guanylureido cephalosporin, chlorobenzoylureido cephalosporin, BL-P1654, and carbenicillin on Pseudomonas aeruginosa.利用电子显微镜评估抗生素疗效：胍基脲基头孢菌素、氯苯甲酰脲基头孢菌素、BL-P1654和羧苄青霉素对铜绿假单胞菌的形态学影响。
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本文引用的文献
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Antibiotic-induced alterations in the surface morphology of bacterial cells: a scanning-beam electron miscroscopy study.抗生素诱导的细菌细胞表面形态变化：一项扫描束电子显微镜研究。
J Infect Dis. 1970 Oct;122(4):323-8. doi: 10.1093/infdis/122.4.323.
2
A comparison of the effects of ampicillin on Escherichia coli and proteus mirabilis.氨苄青霉素对大肠杆菌和奇异变形杆菌作用的比较。
J Med Microbiol. 1969 Nov 4;2(4):435-41. doi: 10.1099/00222615-2-4-435.
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Interaction of penicillin with the bacterial cell: penicillin-binding proteins and penicillin-sensitive enzymes.青霉素与细菌细胞的相互作用：青霉素结合蛋白和青霉素敏感酶。
Bacteriol Rev. 1974 Sep;38(3):291-335. doi: 10.1128/br.38.3.291-335.1974.
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Comparison of the responses of Escherichia coli and proteus mirabilis to seven beta-lactam antibodies.大肠杆菌和奇异变形杆菌对七种β-内酰胺抗体反应的比较。
J Infect Dis. 1973 Aug;128(2):211-22. doi: 10.1093/infdis/128.2.211.
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8
Evaluation of antibiotic efficacy using electron microscopy: morphological effects of guanylureido cephalosporin, chlorobenzoylureido cephalosporin, BL-P1654, and carbenicillin on Pseudomonas aeruginosa.利用电子显微镜评估抗生素疗效：胍基脲基头孢菌素、氯苯甲酰脲基头孢菌素、BL-P1654和羧苄青霉素对铜绿假单胞菌的形态学影响。
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