Spector A C
Department of Psychology, University of Florida, Gainesville 32611-2250, USA.
Behav Neurosci. 1995 Feb;109(1):79-90. doi: 10.1037//0735-7044.109.1.79.
This study examined the effects of electrophysiologically placed electrolytic lesions in the gustatory zone of the parabrachial nuclei (PBN) on the rat's taste-guided unconditioned licking of quinine hydrochloride during repeated 10-s trials. Concentration-response functions measured in water-deprived rats before and after surgery significantly shifted to the right as a result of the bilaterally placed lesions. These same rats were tested on their ability to acquire a lithium chloride (LiCl)-based conditioned taste aversion (CTA) to 0.1 M sucrose. Although the largest lesions severely affected performance in both tasks, there was only a modest correlation (r = -.447) between the extent of the lesion-induced shift in the quinine concentration-response curves and the degree of sucrose intake suppression after the first CTA conditioning trial. Thus, PBN lesions can disrupt performance on both tasks, but it appears that the neural processes governing unconditioned responsiveness to quinine may be to some extent dissociable from those subserving acquisition of a sucrose LiCl-based CTA.
本研究检测了在臂旁核（PBN）味觉区进行电生理定位的电解损伤，对大鼠在重复的10秒试验中，由味觉引导的对盐酸奎宁的非条件性舔舐行为的影响。在手术前后对缺水大鼠测量的浓度-反应函数，由于双侧损伤而显著右移。对这些大鼠获取基于氯化锂（LiCl）的对0.1M蔗糖的条件性味觉厌恶（CTA）的能力进行了测试。尽管最大的损伤严重影响了两项任务的表现，但在第一次CTA条件试验后，损伤引起的奎宁浓度-反应曲线的偏移程度与蔗糖摄入抑制程度之间，仅存在适度的相关性（r = -0.447）。因此，PBN损伤会破坏两项任务的表现，但似乎控制对奎宁非条件反应性的神经过程，在某种程度上可能与那些支持基于蔗糖LiCl的CTA习得的神经过程是可分离的。
