Kobayashi T, Ogata H, Luo X X, Xu X
First Department of Anesthesiology, Dokkyo University School of Medicine, Tochigi.
Masui. 1995 Feb;44(2):244-51.
Our previous study reported that 20% (1.5 ml.kg-1 hypertonic saline could significantly improve the disturbances of cerebral oxidative metabolism induced by hemorrhagic hypotension in dogs. The aim of the present study is to evaluate if 7.5% hypertonic saline induces circulatory improvement. Ten dogs were randomly divided into two groups of 5 each resuscitated with either physiological saline as control or 7.5% hypertonic saline (4 ml.kg-1) after their mean arterial blood pressure decreased to 35 mmHg for 45 minutes by hemorrhage. The changes of cerebral tissue oxy- and deoxyhemoglobin, cerebral blood volume (total hemoglobin), and oxy-cytochrome aa3 were continuously monitored by near infrared spectroscopy throughout the experiment. The experimental result showed that oxy-hemoglobin, oxy-cytochrome aa3, and cerebral blood volume decreased but deoxyhemoglobin increased significantly 45 minutes after hemorrhage. Treatment with 7.5% hypertonic saline significantly restored these variables except for cerebral blood volume and all the animals survived to the end of experiment. But in the control group treated with the same dose of physiological saline, the above variables improved little compared with the baseline; and all the animals died before the end of 60 min experimental observation. Therefore we conclude that 7.5% hypertonic saline (4 ml.kg-1) can also effectively improve the disturbance of cerebral oxidative metabolism induced by hemorrhagic hypotension.
我们之前的研究报道称，20%（1.5毫升·千克⁻¹）高渗盐水可显著改善犬失血性低血压所致的脑氧化代谢紊乱。本研究的目的是评估7.5%高渗盐水是否能改善循环。将10只犬随机分为两组，每组5只，通过出血使平均动脉血压降至35 mmHg并维持45分钟后，分别用生理盐水作为对照或7.5%高渗盐水（4毫升·千克⁻¹）进行复苏。在整个实验过程中，通过近红外光谱连续监测脑组织氧合血红蛋白、脱氧血红蛋白、脑血容量（总血红蛋白）和氧细胞色素aa3的变化。实验结果显示，出血后45分钟，氧合血红蛋白、氧细胞色素aa3和脑血容量降低，而脱氧血红蛋白显著增加。用7.5%高渗盐水治疗可显著恢复这些指标，但脑血容量除外，所有动物均存活至实验结束。但在给予相同剂量生理盐水的对照组中，上述指标与基线相比改善甚微；所有动物在60分钟实验观察结束前死亡。因此，我们得出结论，7.5%高渗盐水（4毫升·千克⁻¹）也可有效改善失血性低血压所致的脑氧化代谢紊乱。
