Gürdöl F, Genç S, Yalçin O, Gültepe M
Department of Chemical Pathology and Human Metabolism, Royal Free Hospital, London, UK.
Biol Neonate. 1995;67(1):34-8. doi: 10.1159/000244140.
Prolidase (EC: 3.4.13.9) catalyses the hydrolysis of the peptide bond involving the imino nitrogen of proline or hydroxyproline. Because of the high proportion of imino acids in collagen, this enzyme plays an important role in its degradation. Since collagen turnover rate is expected to be high during fetal growth, the level of prolidase activity may reflect the degree of fetal maturation. In this study, amniotic fluid prolidase I activity was measured in term and preterm pregnancies. Lecithin concentration, which has been widely used for predicting fetal lung maturity, was also measured. Prolidase I activity was positively correlated with lecithin levels (n = 30; r = 0.42; p < 0.02), and also with birth weight of the babies (n = 30; r = 0.52; p < 0.01) in the term-mature group. Dysmature babies had significantly lower prolidase I activity in the amniotic fluid which was thought to be indicative of growth retardation.
脯氨酰肽酶（EC：3.4.13.9）催化涉及脯氨酸或羟脯氨酸亚氨基氮的肽键水解。由于胶原蛋白中亚氨基酸比例较高，该酶在其降解过程中起重要作用。鉴于胎儿生长期间胶原蛋白周转率预计较高，脯氨酰肽酶活性水平可能反映胎儿成熟程度。在本研究中，对足月和早产妊娠的羊水脯氨酰肽酶I活性进行了测定。还测量了已广泛用于预测胎儿肺成熟度的卵磷脂浓度。在足月成熟组中，脯氨酰肽酶I活性与卵磷脂水平呈正相关（n = 30；r = 0.42；p < 0.02），也与婴儿出生体重呈正相关（n = 30；r = 0.52；p < 0.01）。发育不成熟的婴儿羊水中脯氨酰肽酶I活性显著较低，这被认为表明生长迟缓。
