Foley J
South West Regional Health Authority, Chelsea, London, UK.
Early Hum Dev. 1995 Jan 30;40(2):145-56. doi: 10.1016/0378-3782(94)01602-L.
The birth-weight ratio, a convenient measure of fetal growth, has been used to assess the importance of antecedent and perinatal factors in a retrospective analysis of 605 cases of congenital cerebral palsy. All had been seen by the author at a special clinic over a period of three decades. The ratio (normally 1) is high in the very premature, falls in the middle of the third trimester, then begins to rise again at term. Abnormalities of pregnancy, or a history of maternal pregnancy-losses, depress the ratio perceptibly. In both singletons and twins, there is no significant relationship between a low ratio and the severity of the clinical condition, and presumably the extent of the brain damage. The findings suggest that growth retardation is an association and not a cause of perinatal vascular-anoxic lesions.
出生体重比是衡量胎儿生长的一个便捷指标，在对605例先天性脑瘫病例的回顾性分析中，该指标被用于评估前期因素和围产期因素的重要性。在三十年的时间里，作者在一家特殊诊所诊治了所有这些病例。该比值（正常为1）在极早产儿中较高，在妊娠晚期中期下降，然后在足月时又开始上升。妊娠异常或有母亲流产史会明显降低该比值。在单胎和双胎中，低比值与临床病情严重程度之间没有显著关系，大概与脑损伤程度也无显著关系。研究结果表明，生长迟缓是一种关联因素，而非围产期血管缺氧性病变的原因。
