[甲状旁腺激素在分子生物学方面的调节]
[Regulation of parathyroid hormone in molecular biological aspect].
作者信息
Tokumaru H, Seino Y
机构信息
Department of Pediatrics, Okayama University Medical School.
出版信息
Nihon Rinsho. 1995 Apr;53(4):811-6.
PMID:7752465
Abstract
The synthesis of human parathyroid hormon (PTH) is controlled by extracellular Ca2+ concentration and 1,25 (OH)2D3, independently, nCaRE (negative calcium responsive element) and nVDRE (negative vitamin D responsive element) have been detected on 5' flanking region of human PTH gene. And also gene mutations of PTH in hereditary hypoparathyroidism was discovered in hereditary hypoparathyroidism.
摘要
人甲状旁腺激素（PTH）的合成分别受细胞外Ca2+浓度和1,25（OH）2D3的调控，在人PTH基因的5'侧翼区已检测到负钙反应元件（nCaRE）和负维生素D反应元件（nVDRE）。此外，在遗传性甲状旁腺功能减退症中还发现了PTH的基因突变。
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