Burge P S, Calvert I A, Trethowan W N, Harrington J M
Occupational Health Unit, Royal Shrewsbury Hospital.
Occup Environ Med. 1995 Feb;52(2):105-9. doi: 10.1136/oem.52.2.105.
To determine whether the respiratory symptoms and decrements in lung function found in manufacturers of ceramic fibres are related to exposure to the respirable fibre or inspirable mass constituents of the air in the working environment.
Cross sectional survey of all current European primary producers of ceramic fibre was carried out, with measurement of exposure to respiratory fibres by personal samplers that measured inspirable and total mass, together with a health survey with an expanded respiratory questionnaire and standardised measurement of lung function. Odds ratios were calculated for symptoms and current exposure by multiple logistic regression, and multiple linear regression coefficients for lung function related to cumulative exposures controlled for the effects of respirable fibre and inspirable mass separately and together.
Significant effects of current exposure to both inspirable dust and respirable fibres were related to dry cough, stuffy nose, eye and skin irritation and breathlessness. The decrements found in smokers and to some extent in ex-smokers in forced expiratory volume in one second and forced expiratory flow from 25% to 75% of expiratory volume, seem to be related to the respirable fibres rather than the inspirable mass constituents of the environment.
Current symptoms were related to both current exposure to inspirable dust and respirable fibre. The decrements in lung function were related to the fibre constituent of the exposure.
确定在陶瓷纤维制造商中发现的呼吸道症状和肺功能下降是否与工作环境空气中可吸入纤维或可吸入颗粒物成分的暴露有关。
对所有欧洲当前的陶瓷纤维主要生产商进行横断面调查，使用测量可吸入和总质量的个人采样器测量呼吸道纤维暴露情况，并进行健康调查，采用扩展的呼吸问卷和标准化的肺功能测量。通过多元逻辑回归计算症状与当前暴露的比值比，以及与累积暴露相关的肺功能的多元线性回归系数，分别和共同控制可吸入纤维和可吸入颗粒物的影响。
当前暴露于可吸入粉尘和可吸入纤维均对干咳、鼻塞、眼睛和皮肤刺激以及呼吸急促有显著影响。在吸烟者以及在一定程度上在前吸烟者中发现的一秒用力呼气量和呼气量25%至75%时的用力呼气流量下降，似乎与可吸入纤维而非环境中的可吸入颗粒物成分有关。
当前症状与当前暴露于可吸入粉尘和可吸入纤维均有关。肺功能下降与暴露中的纤维成分有关。
