Longworth D L
Department of Infectious Diseases, Cleveland Clinic Foundation, Ohio, USA.
Pediatr Clin North Am. 1995 Jun;42(3):649-64. doi: 10.1016/s0031-3955(16)38983-0.
Malaria remains a significant cause of childhood morbidity and mortality worldwide. Drug resistance in Plasmodium falciparum has become widespread in the past 30 years, and in some parts of the world multidrug resistance is common. Chloroquine resistance in Plasmodium vivax has recently been recognized in Indonesia. The mechanisms of drug resistance have been defined for the antifolate antimalarial agents but remain incompletely understood for the quinolines. Judicious use of antimalarial compounds will be essential to prevent the emergence and spread of further drug resistance. The history, geographic distribution, and mechanisms of drug resistance are reviewed, together with current recommendations regarding prophylaxis and therapy.
疟疾仍是全球儿童发病和死亡的一个重要原因。在过去30年里，恶性疟原虫的耐药性已广泛传播，在世界一些地区，多重耐药现象很常见。间日疟原虫对氯喹的耐药性最近在印度尼西亚被发现。抗叶酸抗疟药的耐药机制已明确，但喹啉类药物的耐药机制仍未完全了解。明智地使用抗疟化合物对于预防进一步的耐药性出现和传播至关重要。本文综述了耐药性的历史、地理分布和机制，以及目前关于预防和治疗的建议。
