敌敌畏应激效应的治疗。

Treatment of the stressogenic effect of dichlorvos.

Kassa J, Bajgar J

Military Medical Academy Hradec Králové.

Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove. 1994;37(1):29-32.

Abstract

Changes of corticosterone level in the plasma and tyrosine aminotransferase (TAT) in the liver following treated and untreated dichlorvos poisoning in rats were studied. 2. Corticosterone level during untreated poisoning was increased only. During treated dichlorvos poisoning and following antidotal treatment without poisoning, no significant changes of corticosterone level were observed. 3. Expressive increase of TAT activity in the third and 24th hour of untreated poisoning was demonstrated. Following treatment of dichlorvos poisoning with atropine, obidoxime and diazepam, the delayed and lower increase of TAT activity was observed. Following antidotal treatment without poisoning, no significant changes of TAT activity except its decrease in the third hour were demonstrated. 4. The treatment of dichlorvos poisoning practically eliminate stressogenic effects of dichlorvos. Moreover, the markers could be used for evaluating the effects of antidotes against organophosphate poisoning.

摘要

研究了大鼠经敌敌畏中毒处理和未处理后血浆中皮质酮水平及肝脏中酪氨酸转氨酶（TAT）的变化。2. 仅在未处理中毒期间皮质酮水平升高。在经敌敌畏中毒处理及解毒治疗但未中毒的情况下，未观察到皮质酮水平有显著变化。3. 未处理中毒的第3小时和第24小时显示TAT活性显著增加。用阿托品、双复磷和地西泮治疗敌敌畏中毒后，观察到TAT活性延迟且较低程度的增加。在解毒治疗但未中毒的情况下，除第3小时TAT活性降低外，未显示出TAT活性有显著变化。4. 敌敌畏中毒的治疗实际上消除了敌敌畏的应激源效应。此外，这些标志物可用于评估抗有机磷中毒解毒剂的效果。