Velasco M, Gallardo E, Plaja J, Guevara J
Clin Pharmacol Ther. 1976 Jul;20(1):31-5. doi: 10.1002/cpt197620131.
Cumulative doses of clonidine were administered intravenously to 8 hypertensive patients to a maximal dose of 100 mug or a blood pressure fall to normal. There was a reduction in mean arterial pressure of 35.6 mm Hg (p less than 0.001), accompanied by a decrease in heart rate of 11.8 bpm (p less than 0.001). There was also a significant linear relationship between the reduction in blood pressure and the intravenous log dose of clonidine with 6.5-fold difference in delta MAP/dose potency. There was no correlation between the baseline blood pressure and the slopes of dose-blood pressure response curves or the reduction in mean arterial pressure; the rate of the decline of the hypotensive effect of clonidine varied widely between patients and was not related to baseline blood pressure.
对8名高血压患者静脉注射可乐定累积剂量，最大剂量为100微克或血压降至正常水平。平均动脉压降低了35.6毫米汞柱（p<0.001），同时心率降低了11.8次/分钟（p<0.001）。血压降低与可乐定静脉注射对数剂量之间也存在显著的线性关系，平均动脉压/剂量效力相差6.5倍。基线血压与剂量-血压反应曲线的斜率或平均动脉压降低之间无相关性；可乐定降压作用的下降速率在患者之间差异很大，且与基线血压无关。
