May A C, Blundell T L
Department of Crystallography, Birkbeck College, University of London, UK.
Curr Opin Biotechnol. 1994 Aug;5(4):355-60. doi: 10.1016/0958-1669(94)90043-4.
Most automated methods for protein modelling rely on the assembly of rigid fragments from known three-dimensional structures. Although the modelling of side chains has received attention recently, loop regions continue to be neglected, and these conformations contribute most errors to models. Comparative modelling procedures using distance restraints are particularly useful for modelling distantly related proteins with a common fold. Progress has also recently been made in the automatic evaluation of model structures.
大多数蛋白质建模的自动化方法依赖于从已知三维结构中组装刚性片段。尽管侧链建模最近受到了关注，但环区仍然被忽视，而这些构象给模型带来了最多的误差。使用距离约束的比较建模程序对于构建具有共同折叠的远亲蛋白质模型特别有用。最近在模型结构的自动评估方面也取得了进展。
