1,6-二氯-1,6-二脱氧-D-果糖对猪精子糖酵解的抑制作用
Inhibition of glycolysis in boar spermatozoa by 1,6-dichloro-1,6-dideoxy-D-fructose.
作者信息
Jones A R, Morin C
机构信息
Department of Biochemistry, University of Sydney, NSW, Australia.
出版信息
Biochim Biophys Acta. 1995 May 11;1244(1):141-6. doi: 10.1016/0304-4165(94)00212-g.
PMID:7766650
Abstract
The dichloro-analogue of D-fructose 1,6-bisphosphate, 1,6-dichloro-1,6-dideoxy-D-fructose, is a weak substrate for boar sperm aldolase which converts it to (S)-3-chlorolactaldehyde and 3-chloro-1-hydroxypropanone in vitro. Production of these chloro-trioses leads to the strong inhibition of glyceraldehyde-3-phosphate dehydrogenase, the weak inhibition of triosephosphate isomerase and the transient inhibition of aldolase.
摘要
D-果糖1,6-二磷酸的二氯类似物，1,6-二氯-1,6-二脱氧-D-果糖，是公猪精子醛缩酶的一种弱底物，该酶在体外可将其转化为(S)-3-氯代乙醛和3-氯-1-羟基丙酮。这些氯代丙糖的产生会导致甘油醛-3-磷酸脱氢酶受到强烈抑制，磷酸丙糖异构酶受到微弱抑制，醛缩酶受到短暂抑制。
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