Krägeloh-Mann I, Petersen D, Hagberg G, Vollmer B, Hagberg B, Michaelis R
Department of Child Neurology, University of Tübingen, Germany.
Dev Med Child Neurol. 1995 May;37(5):379-97. doi: 10.1111/j.1469-8749.1995.tb12022.x.
MRI of the brain was performed on 56 children with bilateral spastic cerebral palsy (CP) at a mean age of 10.7 years. Specific pathology was found in 91 per cent; periventricular leukomalacia was present in 42 per cent of term- and 87 per cent of preterm-born children. Parasagittal subcorticocortical injury, multicystic encephalomalacia and basal ganglia lesions were identified in 16 per cent, in all but one associated with severe peri-/neonatal events at term or near term. Maldevelopment comprised 9 per cent, all but one found in term-born children. MRI morphology correlated strikingly with outcome. Periventricular leukomalacia was associated with more severe disability in term- than preterm-born children.
对56名平均年龄为10.7岁的双侧痉挛型脑瘫（CP）患儿进行了脑部MRI检查。91%发现了特定病理；42%的足月儿和87%的早产儿存在脑室周围白质软化。矢状旁皮质下皮质损伤、多囊性脑软化和基底节病变在16%中被发现，除1例之外，所有这些都与足月或接近足月时的严重围产期/新生儿事件相关。发育异常占9%，除1例之外，所有这些都在足月儿中发现。MRI形态与预后显著相关。脑室周围白质软化与足月儿相比早产儿的残疾程度更严重有关。
