Eriksson E, Hedberg M A, Andersch B, Sundblad C
Department of Pharmacology, University of Göteborg, Sweden.
Neuropsychopharmacology. 1995 Apr;12(2):167-76. doi: 10.1016/0893-133X(94)00076-C.
Recent studies indicate that antidepressant drugs with potent serotonin reuptake inhibiting properties are effective in reducing the symptoms of premenstrual syndrome (PMS). In order to elucidate whether all antidepressant drugs are equally effective in the treatment of PMS or whether potent serotonin reuptake inhibition is a prerequisite for reducing premenstrual complaints, women suffering from severe PMS were treated daily for three menstrual cycles with a selective serotonin reuptake inhibitor, paroxetine (n = 22), or with a selective noradrenaline reuptake inhibitor, maprotiline (n = 21); in addition, a placebo group was included (n = 22). Six symptoms (irritability, depressed mood, tension/anxiety, increased appetite/craving for carbohydrates, bloating, and breast tenderness) were rated by the participants daily throughout the study. With respect to all outcome measurements, the symptom reduction obtained with paroxetine was significantly superior to that obtained with placebo; with respect to irritability, increased appetite/carbohydrate craving, bloating, and breast tenderness, as well as global self-rating, paroxetine was significantly superior also to maprotiline. The clear-cut superiority of paroxetine over maprotiline indicates that not all antidepressant drugs are equally effective in the treatment of PMS; rather, like panic disorder and obsessive compulsive disorder, but in contrast to depression, PMS apparently responds better to serotonin reuptake inhibitors than to antidepressants with a noradrenergic profile.
近期研究表明，具有强效5-羟色胺再摄取抑制特性的抗抑郁药物在减轻经前综合征（PMS）症状方面有效。为了阐明是否所有抗抑郁药物在治疗PMS时都同样有效，或者强效5-羟色胺再摄取抑制是否是减轻经前不适的先决条件，对患有严重PMS的女性进行了为期三个月经周期的每日治疗，一组使用选择性5-羟色胺再摄取抑制剂帕罗西汀（n = 22），另一组使用选择性去甲肾上腺素再摄取抑制剂马普替林（n = 21）；此外，还纳入了一个安慰剂组（n = 22）。在整个研究过程中，参与者每天对六种症状（易怒、情绪低落、紧张/焦虑、食欲增加/对碳水化合物的渴望、腹胀和乳房触痛）进行评分。就所有结果测量而言，帕罗西汀获得的症状减轻显著优于安慰剂；就易怒、食欲增加/对碳水化合物的渴望、腹胀和乳房触痛以及总体自我评分而言，帕罗西汀也显著优于马普替林。帕罗西汀相对于马普替林的明显优势表明，并非所有抗抑郁药物在治疗PMS时都同样有效；相反，与恐慌症和强迫症一样，但与抑郁症不同，PMS显然对5-羟色胺再摄取抑制剂的反应比对具有去甲肾上腺素能特征的抗抑郁药物更好。
