血液与精液中α-1-抗胰蛋白酶（PI）多态性的相关性
Correlation of alpha-1-antitrypsin (PI) polymorphism between blood and semen.
作者信息
Sawazaki K, Takeshita H, Tenjo E, Nadano D, Yasuda T, Iida R, Kishi K
机构信息
Department of Legal Medicine, Fukui Medical School, Japan.
出版信息
Nihon Hoigaku Zasshi. 1995 Apr;49(2):65-9.
The correlation between isoprotein types of alpha-1-antitrypsin (PI) in blood and semen samples from the same individual was determined in 48 Japanese men by the combined technique of isoelectric focusing with immobilized pH gradients and immunoblotting. Five common PI types (M1, M1M2, M1M3, M2 and M2M3) were detected in the blood plasma samples. However, PI-specific bands in semen migrated more cathodally than those in plasma into a pI region of approximately 5.05, and about 17% of the semen samples could not be phenotyped: the rest were easily phenotyped and their PI types were found to correlate with the type found in the corresponding blood samples. PI typing could therefore provide an additional discriminant characteristic for the forensic examination of individualization from semen samples.
通过固定化pH梯度等电聚焦和免疫印迹相结合的技术，对48名日本男性同一人血液和精液样本中α-1-抗胰蛋白酶（PI）的同蛋白类型之间的相关性进行了测定。在血浆样本中检测到五种常见的PI类型（M1、M1M2、M1M3、M2和M2M3）。然而，精液中PI特异性条带比血浆中的条带向阴极迁移得更多，进入了约5.05的pI区域，约17%的精液样本无法进行表型分析：其余样本很容易进行表型分析，并且发现它们的PI类型与相应血液样本中的类型相关。因此，PI分型可为精液样本个体识别的法医检验提供额外的鉴别特征。
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