Pandit A A, Khilnani P H, Prayag A S
Department of Pathology, Seth Gordhandas Sunderdas Medical College, Parel, Bombay, India.
Diagn Cytopathol. 1995 Feb;12(1):23-7. doi: 10.1002/dc.2840120106.
In tuberculous lymphadenitis, FNAC smears sometimes reveal only caseous necrosis without epithelioid cell granuloma. They pose a diagnostic problem, if AFB staining is negative. The diagnostic clue noticed in these cases was presence of multiple pink, homogenous structures with irregular shape and well-defined margins: "eosinophilic structures" (ES). The purpose of the present study is to find out the nature of ES and their role in the diagnosis of tuberculosis. Seventy FNAC smears from documented cases of tuberculous lymphadenitis were classified according to their cytomorphological features. The association and relation of ES with other morphological criteria was noted. Immunoperoxidase staining was performed to find out the reactivity of ES to tuberculous antigen. Its intensity of positivity was compared with epithelioid cell granuloma and degenerating granuloma. It was concluded that ES are degenerated granuloma and thus form an extended diagnostic criterion.
在结核性淋巴结炎中，细针穿刺抽吸活检（FNAC）涂片有时仅显示干酪样坏死，而无上皮样细胞肉芽肿。如果抗酸杆菌（AFB）染色为阴性，这些涂片会带来诊断难题。在这些病例中发现的诊断线索是存在多个粉红色、均质的结构，形状不规则且边缘清晰：“嗜酸性结构”（ES）。本研究的目的是确定ES的性质及其在结核病诊断中的作用。根据细胞形态学特征，对70例有记录的结核性淋巴结炎病例的FNAC涂片进行分类。记录ES与其他形态学标准的关联和关系。进行免疫过氧化物酶染色以确定ES对结核抗原的反应性。将其阳性强度与上皮样细胞肉芽肿和退化性肉芽肿进行比较。得出的结论是，ES是退化性肉芽肿，因此构成了一个扩展的诊断标准。
