二氨基酸新型尿素和亚硝基脲衍生物的合成及其抗HIV活性
Synthesis and anti-HIV activity of new urea and nitrosourea derivatives of diamino acids.
作者信息
Dulude H, Salvador R, Gallant G
机构信息
Medicinal Chemistry Laboratory, Faculty of Pharmacy, University of Montreal, Quebec, Canada.
出版信息
Bioorg Med Chem. 1995 Feb;3(2):151-60. doi: 10.1016/0968-0896(95)00008-5.
PMID:7796048
Abstract
A series of N1-methyl,N1-allyl,N1-(2-chloroethyl) and N1-propargyl urea and nitrosourea derivatives of diamino acids (L-ornithine and L-lysine) was synthesized and was shown to have weak activity in counteracting the cytopathic effects of the HIV-1 on a T4 lymphocyte cell line (CEM-IW). However, selected compounds may possess some immunomodulatory activity.
摘要
合成了一系列二氨基酸（L-鸟氨酸和L-赖氨酸）的N1-甲基、N1-烯丙基、N1-(2-氯乙基)和N1-炔丙基脲及亚硝基脲衍生物，结果显示它们在对抗HIV-1对T4淋巴细胞系（CEM-IW）的细胞病变效应方面具有微弱活性。然而，某些选定的化合物可能具有一定的免疫调节活性。
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