Piasecki C, Chin J, Greenslade L, McIntyre N, Burroughs A K, McCormick P A
Department of Anatomy, Royal Free Hospital and School of Medicine, London.
Gut. 1995 May;36(5):654-6. doi: 10.1136/gut.36.5.654.
Changes in mucosal blood flow may be important in the pathogenesis of many conditions. Study of mucosal blood perfusion is difficult, and available methods have significant technical limitations. This study describes the development of an instrument for endoscopy, which indicates blood flow indirectly, by measuring the quantity of tissue oxygen that can diffuse from the mucosa to a luminal surface electrode. The instrument was used through an endoscope in patients with portal hypertension (n = 14), scleroderma (n = 3), disease controls (n = 7), and normal controls (n = 11). In portal hypertension readings were one quarter that in normal controls in both antrum (geometric mean (SEM) 35 (1.1)), nanoamps v 137 (1.1), and upper corpus 34 (1.1) v 125 (1.1)). Scleroderma patients showed greatly reduced oxygen readings in both antrum (18 (1.2)) and corpus (24 (1.2)), an expected but hitherto undiscovered result. These differences are highly significant (p = 0.0001), and the findings suggest that tissue hypoxia may contribute to mucosal changes in portal hypertensive gastropathy and in scleroderma.
黏膜血流变化在许多疾病的发病机制中可能起重要作用。黏膜血流灌注的研究具有难度，现有方法存在显著的技术局限性。本研究描述了一种用于内镜检查的仪器的研发情况，该仪器通过测量从黏膜扩散到腔内表面电极的组织氧量来间接指示血流。该仪器通过内镜应用于门静脉高压患者（n = 14）、硬皮病患者（n = 3）、疾病对照组（n = 7）和正常对照组（n = 11）。在门静脉高压患者中，胃窦部的读数是正常对照组的四分之一（几何均数（标准误）35（1.1）纳安对137（1.1）），胃体上部为34（1.1）对125（1.1））。硬皮病患者胃窦部（18（1.2））和胃体部（24（1.2））的氧读数均大幅降低，这是一个预期但此前未被发现的结果。这些差异具有高度显著性（p = 0.0001），研究结果表明组织缺氧可能导致门静脉高压性胃病和硬皮病的黏膜改变。
