Inoue T, Shigeta M, Mochizuki H, Shimizu T, Morikawa A, Suzuki H, Watanabe N, Tateno M, Oriuchi N, Hirano T
Department of Nuclear Medicine, Gunma University, School of Medicine, Maebashi, Japan.
J Nucl Med. 1995 Jan;36(1):73-7.
The diuretic furosemide has been reported to have a protective effect on allergic asthmatic reactions. This study was performed to investigate the effect of aerosolized furosemide on the lung clearance of 99mTc-diethylene triamine pentaacetic acid (99mTc-DTPA).
Pulmonary clearance rates of 99mTc-DTPA were measured by a computerized gamma camera with and without the inhalation of aerosol furosemide in 6 nonsmoking normal volunteers (Group 1), 7 smokers without pulmonary disease (Group 2) and 11 patients with asthma (Group 3).
None of the six normal volunteers showed significant effects of inhaled furosemide on the 99mTc-DTPA clearance rates. Three of seven smokers presented an accelerated 99mTc-DTPA clearance by inhaled furosemide and the other four showed no significant change of 99mTc-DTPA clearance by furosemide inhalation. However, in 10 of 11 patients with asthma, there was significant suppression of 99mTc-DTPA clearance by furosemide inhalation.
Asthmatics possess a furosemide-sensitive mechanism. Pulmonary aerosol scintigraphy with 99mTc-DTPA will be useful in predicting the effect of inhaled furosemide therapy.
据报道，利尿剂速尿对过敏性哮喘反应有保护作用。本研究旨在探讨雾化速尿对99m锝-二乙三胺五乙酸（99mTc-DTPA）肺清除率的影响。
在6名不吸烟的正常志愿者（第1组）、7名无肺部疾病的吸烟者（第2组）和11名哮喘患者（第3组）中，使用计算机γ相机测量吸入雾化速尿前后99mTc-DTPA的肺清除率。
6名正常志愿者中，吸入速尿对99mTc-DTPA清除率均无显著影响。7名吸烟者中有3名吸入速尿后99mTc-DTPA清除率加快，另外4名吸入速尿后99mTc-DTPA清除率无显著变化。然而，11名哮喘患者中有10名吸入速尿后99mTc-DTPA清除率显著降低。
哮喘患者存在速尿敏感机制。99mTc-DTPA肺气溶胶闪烁扫描有助于预测吸入速尿治疗的效果。
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