小剂量阿立哌唑改善部分精神分裂症缺陷症状。
Improvement of some schizophrenic deficit symptoms with low doses of amisulpride.
作者信息
Paillère-Martinot M L, Lecrubier Y, Martinot J L, Aubin F
机构信息
Department of Child and Adolescent Psychiatry, Hôpital de la Salpêtrière, Paris, France.
出版信息
Am J Psychiatry. 1995 Jan;152(1):130-4. doi: 10.1176/ajp.152.1.130.
OBJECTIVE
The authors assessed the effects on primary negative symptoms of low doses of amisulpride, a substituted benzamide neuroleptic with high affinity for D2 and D3 dopamine receptors.
METHOD
Young, drug-free schizophrenic patients with pure negative symptoms participated in a 6-week double-blind trial of placebo (N = 10) or low-dose amisulpride (N = 10). They were assessed with the Scale for the Assessment of Negative Symptoms.
RESULTS
Amisulpride significantly improved negative symptoms. Improvement in avolition, attentional impairment, and retardation was significantly greater with amisulpride than with placebo.
CONCLUSIONS
These findings suggest that some primary negative symptoms may be directly affected by low doses of benzamide neuroleptics.
目的
作者评估了低剂量氨磺必利（一种对D2和D3多巴胺受体具有高亲和力的取代苯甲酰胺类抗精神病药物）对原发性阴性症状的影响。
方法
患有单纯阴性症状的年轻、未服用过药物的精神分裂症患者参与了一项为期6周的安慰剂（N = 10）或低剂量氨磺必利（N = 10）双盲试验。使用阴性症状评估量表对他们进行评估。
结果
氨磺必利显著改善了阴性症状。与安慰剂相比，氨磺必利对意志缺乏、注意力损害和迟缓的改善更为显著。
结论
这些发现表明，低剂量的苯甲酰胺类抗精神病药物可能直接影响某些原发性阴性症状。
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