Gilchrist J S, Czubryt M P, Pierce G N
Division of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, Winnipeg, Manitoba, Canada.
Mol Cell Biochem. 1994 Jun 15;135(1):79-88. doi: 10.1007/BF00925963.
Calcium has long been known to play a role as a key cytoplasmic second messenger, but until relatively recently its possible involvement in nuclear signal transduction and the regulation of nuclear events has not been extensively studied. Evidence revealing the presence of transmembrane nuclear Ca2+ gradients and a variety of intranuclear Ca2+ binding proteins has fueled renewed interest in this key ion and its involvement in cell-cycle timing and division, gene expression, and protein activation. This review will offer an overview of the current state of knowledge and theory regarding calcium orchestration of nuclear functions and events and discuss possible future directions in this field of study.
长期以来，人们一直认为钙作为关键的细胞质第二信使发挥作用，但直到最近，其在核信号转导及核事件调控中的潜在作用尚未得到广泛研究。揭示跨膜核Ca2+梯度和多种核内Ca2+结合蛋白存在的证据，激发了人们对这种关键离子及其在细胞周期定时与分裂、基因表达和蛋白质激活中作用的新兴趣。本综述将概述目前关于钙对核功能和事件调控的知识和理论现状，并讨论该研究领域未来可能的发展方向。
