双脒苯脲在山羊血浆和脑脊液中的药代动力学
Pharmacokinetics of diminazene in plasma and cerebrospinal fluid of goats.
作者信息
Mamman M, Peregrine A S
机构信息
International Laboratory for Research on Animal Diseases (ILRAD), Nairobi, Kenya.
出版信息
Res Vet Sci. 1994 Sep;57(2):253-5. doi: 10.1016/0034-5288(94)90068-x.
The pharmacokinetics of diminazene in the cerebrospinal fluid (CSF) and plasma of five uninfected goats treated with single intramuscular doses of 3.5 mg diminazene base kg-1 bodyweight was investigated. The concentrations of the drug were determined by high performance liquid chromatography, and were three to four times lower in CSF than in plasma. The kinetics of the drug in CSF and plasma differed significantly with respect to Cmax, tmax, AUC0-48h, AUMC0-48h, Cl and Vd(ss).
研究了5只未感染山羊单次肌内注射3.5mg双脒苯脲碱/ kg体重后，双脒苯脲在脑脊液（CSF）和血浆中的药代动力学。药物浓度通过高效液相色谱法测定，CSF中的浓度比血浆中的低三到四倍。药物在CSF和血浆中的动力学在Cmax、tmax、AUC0 - 48h、AUMC0 - 48h、Cl和Vd(ss)方面有显著差异。
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