[急性胰腺炎大鼠肺容量、肺容积及通过全身体积描记法测量的用力呼气流量：实验研究]

[Pulmonary capacity and volume, forced expiratory flow measured by whole body plethysmography in acute pancreatitis: experimental study in rats].

作者信息

Chaib E, Saldiva P H, Criado P M, Sakae R S, Machado M C

机构信息

Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo.

出版信息

Rev Hosp Clin Fac Med Sao Paulo. 1994 Mar-Apr;49(2):60-3.

PMID:7817094

Abstract

Up to 70% of the patients with acute pancreatitis suffer a sort of pulmonary dysfunction. Twenty-nine rats with pancreatitis induced by 2.5% taurocholic and solution have been studied by whole body plethysmography in order to evaluate pulmonary volumes and expiratory flows. They were divided into three groups: a sham operation control group-10 rats,a two pancreatitis group-10 rats and eight hours pancreatitis group-9 rats. The results showed a significant decrease of expiratory reserve volumes and forced vital capacity (FVC) and also a significant increase of expiratory flow in the 2 and 8 hours pancreatitis groups. These findings indicate a restrictive pneumopathy.

摘要

高达70%的急性胰腺炎患者会出现某种肺功能障碍。为了评估肺容量和呼气流量，对29只由2.5%牛磺胆酸钠溶液诱导胰腺炎的大鼠进行了全身体积描记法研究。它们被分为三组：假手术对照组10只大鼠、胰腺炎组10只大鼠和胰腺炎8小时组9只大鼠。结果显示，胰腺炎2小时组和8小时组的呼气储备量和用力肺活量（FVC）显著降低，呼气流量也显著增加。这些发现表明存在限制性肺病。