Gajkowska B, Gadamski R, Frontczak-Baniewicz M
Laboratory of the Ultrastructure of the Central Neurons System, Polish Academy of Sciences, Warsaw.
Acta Neurobiol Exp (Wars). 1994;54(3):219-25.
The influence of staphylococcal alpha-toxin on the ultrastructure of hypothalamo-neurohypophysical system in the brain (nucleus supraopticus, nucleus paraventricularis, neurohypophysis) was studied in the rat. In neurohypophysis, an area lacking blood-brain barrier, alpha-toxin damaged both neuronal endings and capillary vessels. On the other hand in hypothalamus, where blood-brain barrier is present structural alterations were much less pronounced. Reactive gliosis, accordant with cell damage, was observed in the entire neurosecretory system. Putative mechanisms leading to brain damage after systemic administration of alpha-toxin, including direct disruption of cell membrane and induction of nitric oxide synthesis, are discussed.
在大鼠中研究了葡萄球菌α毒素对脑内下丘脑 - 神经垂体系统（视上核、室旁核、神经垂体）超微结构的影响。在缺乏血脑屏障的神经垂体区域，α毒素对神经末梢和毛细血管均造成损伤。另一方面，在存在血脑屏障的下丘脑，结构改变则不太明显。在整个神经分泌系统中均观察到与细胞损伤一致的反应性胶质增生。讨论了全身给予α毒素后导致脑损伤的可能机制，包括细胞膜的直接破坏和一氧化氮合成的诱导。
