A clinical attempt to avoid hyperacute rejection by F (ab') 2 organ pretreatment.

An attempt was made to, in a controlled study, avoid hyperacute rejection by pretreatment of a renal graft pepsine digested anti-donor antibodies. It turned out to be unsuccessful, but there were some indications that the chain of events that leads to the destruction of the graft was delayed for some hours. There may be several reasons for this failure but we think it is possible to improve this method even if its importance in clinical use is still doubtful.