等离子体处理对植入绵羊股动脉的钽斯特雷克支架的影响。
Plasma treatment effects on the tantalum Strecker stent implanted in femoral arteries of sheep.
作者信息
Crochet D, Grossetête R, Bach-Lijour B, Sagan C, Lecomte E, Leurent B, Brunel P, Le Nihouannen J C
机构信息
Centre Hémodynamique-Radiologie Thoracique, Hôpital G. et R. Laënnec, CHR Nantes, France.
出版信息
Cardiovasc Intervent Radiol. 1994 Sep-Oct;17(5):285-91. doi: 10.1007/BF00192453.
PURPOSE
To evaluate the effects of plasma treatment, a cleaning process for removal of organic contaminants from the knit-wire surface of tantalum Strecker stents, on biocompatibility and thrombogenicity.
METHODS
A treated or untreated stent was randomly implanted in both femoral arteries of 15 sheep studied for periods of 4 (group 1), 15 (group 2), or 42 (group 3) days. Patency, histological changes, and mechanical effects were compared by means of radiologic and pathologic controls.
RESULTS
Plasma treatment did not influence overall patency (93.3% vs 86.7%), maximal neointimal hyperplasia in groups 2 and 3 (801 +/- 123 vs 733 +/- 179 microns), or media thinning in any group (254 +/- 92 vs 285 +/- 72 microns), but modified the elastic properties of the stents by limiting (p = 0.01) shortening at implantation.
CONCLUSION
Plasma treatment does not affect the biocompatibility and thrombogenicity of Strecker stents implanted in normal femoral arteries of sheep but modifies their elastic properties. Further studies are needed to account for this effect.
目的
评估等离子体处理（一种从钽斯特雷克支架的编织丝表面去除有机污染物的清洁工艺）对生物相容性和血栓形成性的影响。
方法
将经过处理或未处理的支架随机植入15只绵羊的双侧股动脉，研究时间分别为4天（第1组）、15天（第2组）或42天（第3组）。通过放射学和病理学对照比较通畅情况、组织学变化和机械效应。
结果
等离子体处理不影响总体通畅率（93.3%对86.7%），不影响第2组和第3组的最大内膜增生（801±123对733±179微米），也不影响任何组的中膜变薄（254±92对285±72微米），但通过限制（p = 0.01）植入时的缩短改变了支架的弹性特性。
结论
等离子体处理不影响植入绵羊正常股动脉的斯特雷克支架的生物相容性和血栓形成性，但改变了其弹性特性。需要进一步研究来解释这种效应。
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