Shu M, Takahashi H, Nagaya K, Hamada T, Akiya S, Imamura S, Ohnishi A, Morimoto I, Hachisuka K
Department of Ophthalmology, University of Occupational and Environmental Health, Hukuoka-ken, Japan.
Nippon Ganka Gakkai Zasshi. 1994 Nov;98(11):1126-30.
To evaluate the relationship between diabetic neuropathy and retinopathy, we examined autonomic nervous function, postural hypotension, nerve conduction velocity and coefficient of variation of R-R intervals. Forty-five non-insulin dependent diabetic cases were classified as no diabetic retinopathy (group A), simple diabetic retinopathy (group B) and proliferative diabetic retinopathy (group C). These groups did not differ in age or gender. The rate of postural hypotension (depression of systolic blood pressure over 30 mmHg) was 0% in group A, 7% in group Bs and 53% in group C. Nerve conduction velocity in both motor and sensory nerve was delayed over 20% in 0% of group A, 8% of group B, and 33% of group C. In CVR-R, 11% of group A and 7% of group B were decreased, and 44% (during rest) and 33% (during deep breathing) of group C was decreased. Between groups A and B there was no statistical difference. But group C had statistically significant difference from other groups, particularly in postural hypotension. Peripheral neuropathy might be closely related to diabetic retinopathy.
为评估糖尿病神经病变与视网膜病变之间的关系，我们检测了自主神经功能、体位性低血压、神经传导速度及R-R间期变异系数。45例非胰岛素依赖型糖尿病患者被分为无糖尿病视网膜病变组（A组）、单纯糖尿病视网膜病变组（B组）和增殖性糖尿病视网膜病变组（C组）。这些组在年龄和性别上无差异。体位性低血压（收缩压下降超过30 mmHg）的发生率在A组为0%，B组为7%，C组为53%。运动神经和感觉神经的神经传导速度延迟超过20%的比例在A组为0%，B组为8%，C组为33%。在R-R间期变异系数（CVR-R）方面，A组的11%和B组的7%降低，C组在静息时44%、深呼吸时33%降低。A组和B组之间无统计学差异。但C组与其他组有统计学显著差异，尤其是在体位性低血压方面。周围神经病变可能与糖尿病视网膜病变密切相关。
