比较碘海醇和51铬-乙二胺四乙酸用于测量肾小球滤过率的实验研究。

Experimental studies comparing iohexol and 51Cr-EDTA for glomerular filtration rate measurements.

作者信息

Lundqvist S, Hietala S O, Karp K

机构信息

Department of Diagnostic Radiology, University Hospital, Umeå, Sweden.

出版信息

Acta Radiol. 1995 Jan;36(1):58-63.

PMID:7833170

Abstract

The total plasma clearance as well as the renal clearance of iohexol were evaluated for determination of the glomerular filtration rate (GFR) in 16 anesthetized pigs. The iohexol levels in urine and plasma were measured by X-ray fluorescence. The total plasma clearance of 1 and 4 ml/kg b.w. of iohexol 300 mg I/ml was compared to the simultaneously as well as nonsimultaneously calculated total plasma clearance of 51Cr-EDTA. The total plasma clearance of 51Cr-EDTA and of iohexol turned out to be equal and independent of the injected dose of iohexol. The injected dose did not have any effect on the renal clearance of iohexol either. It is concluded that iohexol and 51Cr-EDTA are similar as marker substances for determination of the GFR.

摘要

为测定16头麻醉猪的肾小球滤过率（GFR），评估了碘海醇的总血浆清除率及肾脏清除率。通过X射线荧光法测定尿液和血浆中的碘海醇水平。将1 ml/kg体重和4 ml/kg体重的300 mg I/ml碘海醇的总血浆清除率与同时及非同时计算的51Cr - EDTA的总血浆清除率进行比较。结果表明，51Cr - EDTA和碘海醇的总血浆清除率相等，且与碘海醇的注射剂量无关。注射剂量对碘海醇的肾脏清除率也没有任何影响。得出结论，碘海醇和51Cr - EDTA作为测定GFR的标记物质是相似的。