Petrides G, Dhossche D, Fink M, Francis A
Department of Psychiatry and Behavioral Sciences, School of Medicine, SUNY Stony Brook.
Convuls Ther. 1994 Sep;10(3):189-94.
Relapse rates after the acute treatment of affective disorders with drugs or electroconvulsive therapy (ECT) are high (often 50-95%), despite preventive pharmacotherapy. In practice, some patients receive continuation and maintenance ECT after successful treatment of the index episode with ECT. We reviewed the charts of patients with affective illnesses who received continuation ECT (C-ECT) in our inpatient service from 1985 to 1991. In 33 courses of C-ECT, mean intertreatment interval was 10.1 days and the average duration of treatment was 10 weeks. One-year follow-up was available for 21 patients. Seven (33%) patients relapsed and needed re-admission within 1 year. The relapse rate for the patients with delusional depression was 42%, lower than the 95% reported for patients with delusional depression maintained on continuation pharmacotherapy before the C-ECT program started in our facility. No single factor examined was a significant predictor of relapse except C-ECT, which exhibited a sustained prophylactic effect for the year after the index episode.
尽管采用了预防性药物治疗，但使用药物或电休克疗法（ECT）对情感障碍进行急性治疗后的复发率仍然很高（通常为50%-95%）。在实际操作中，一些患者在通过ECT成功治疗首发发作后会接受连续性和维持性ECT治疗。我们回顾了1985年至1991年在我们住院部接受连续性ECT（C-ECT）治疗的情感疾病患者的病历。在33个C-ECT疗程中，平均治疗间隔为10.1天，平均治疗持续时间为10周。对21名患者进行了为期一年的随访。7名（33%）患者在1年内复发并需要再次入院。妄想性抑郁症患者的复发率为42%，低于在我们机构开始C-ECT计划之前接受连续性药物治疗的妄想性抑郁症患者报告的95%。除了C-ECT外，所检查的单一因素均不是复发的显著预测因素，C-ECT在首发发作后的一年中表现出持续的预防作用。
