Okany C C, Akinyanju O O
Department of Haematology, Lagos University Teaching Hospital, Nigeria.
Afr J Med Med Sci. 1993 Jun;22(2):57-60.
The influence of socio-economic status on morbidity was studied in 122 unselected consecutive patients with homozygous sickle cell disease in steady state. They included 65 females and 57 males, divided into three social classes (I, II and III, from highest to lowest). The morbidity indices used were, frequency of bone pain crisis, leg ulceration, growth index and the degree of anaemia as denoted by the mean steady haemoglobin level. It was found that the frequency of bone pain crisis was significantly higher in social class III patients than in social class I and social class II (P < 0.01). Leg ulceration was significantly more common in patients of social class III than in patients of social class I (P < 0.05). There was no correlation between the growth index and social class (r = 0.067, P > 0.05). The mean haemoglobin level was found to fall slightly from the highest to the lowest social class although the differences were not statistically significant. Our findings suggest that socio-economic status has some modifying influence on morbidity in sickle cell disease.
在122例未经挑选的、处于稳定状态的纯合子镰状细胞病连续患者中，研究了社会经济地位对发病率的影响。他们包括65名女性和57名男性，分为三个社会阶层（I、II和III，从最高到最低）。所使用的发病指数为骨痛危象的频率、腿部溃疡、生长指数以及由平均稳定血红蛋白水平表示的贫血程度。结果发现，III类社会阶层患者的骨痛危象频率显著高于I类和II类社会阶层患者（P < 0.01）。III类社会阶层患者的腿部溃疡明显比I类社会阶层患者更常见（P < 0.05）。生长指数与社会阶层之间没有相关性（r = 0.067，P > 0.05）。尽管差异无统计学意义，但发现平均血红蛋白水平从最高社会阶层到最低社会阶层略有下降。我们的研究结果表明，社会经济地位对镰状细胞病的发病率有一定的调节作用。
