额叶癫痫患者的质子磁共振波谱成像
Proton magnetic resonance spectroscopic imaging in patients with frontal lobe epilepsy.
作者信息
Garcia P A, Laxer K D, van der Grond J, Hugg J W, Matson G B, Weiner M W
机构信息
Department of Neurology, University of California, San Francisco 94143.
出版信息
Ann Neurol. 1995 Feb;37(2):279-81. doi: 10.1002/ana.410370222.
Proton magnetic resonance spectroscopic imaging (1H MRSI) has demonstrated decreased N-acetyl compounds (NA) in the epileptogenic hippocampus in patients with temporal lobe epilepsy. We studied 8 patients with frontal lobe epilepsy and found mean NA/creatine (Cr) in the epileptogenic frontal lobe decreased by 27% compared with that of the contralateral homologous region (1.81 +/- 0.36 vs 2.49 +/- 0.60, p < 0.008). In every patient, NA/Cr was decreased in the epileptogenic region by at least 5%. These findings suggest that 1H MRSI may be useful in the presurgical evaluation of patients with frontal lobe epilepsy.
质子磁共振波谱成像（1H MRSI）已证实，颞叶癫痫患者致痫海马区的N-乙酰化合物（NA）含量降低。我们对8例额叶癫痫患者进行了研究，发现致痫额叶的平均NA/肌酸（Cr）含量与对侧同源区域相比降低了27%（分别为1.81±0.36和2.49±0.60，p<0.008）。在每例患者中，致痫区域的NA/Cr至少降低了5%。这些发现表明，1H MRSI可能有助于额叶癫痫患者的术前评估。
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