Niwa M, Shigematsu K, Maeda T, Fujimoto M, Yamashita K, Kataoka Y, Taniyama K
Department of Pharmacology, Nagasaki University School of Medicine, Japan.
Arch Int Pharmacodyn Ther. 1994 May-Jun;327(3):309-29.
The effects of MPC-1304, a newly developed 1,4-dihydropyridine derivative, on blood pressure and hypertensive complications in stroke-prone spontaneously hypertensive rats fed a high-salt diet (0.8% NaCl), were investigated. The antihypertensive effectiveness of nicardipine was used for the purpose of comparison. MPC-1304 and nicardipine were added to the diet, in doses of 0.01% (0.01% MPC-1304 diet), 0.03% (0.03% MPC-1304 diet) and 0.1% (0.1% nicardipine diet), respectively, throughout the experimental period (8 to 30 weeks of age). This chronic ingestion of MPC-1304 and nicardipine inhibited the development of hypertension and reduced the concentration of blood urea nitrogen, creatinine, triglyceride and total cholesterol in serum. Treatment with MPC-1304 inhibited the incidence of cerebral stroke, cardiac fibrosis, proliferative and fibrinoid arteriolitis and malignant nephrosclerosis. There was no significant difference in the antihypertensive effectiveness between 0.01% MPC-1304 and 0.1% nicardipine diets. Thus, MPC-1304 had antihypertensive effects in stroke-prone spontaneously hypertensive rats.
研究了新开发的1,4 - 二氢吡啶衍生物MPC - 1304对喂食高盐饮食（0.8%氯化钠）的易中风自发性高血压大鼠血压及高血压并发症的影响。以尼卡地平的降压效果作为比较对象。在整个实验期（8至30周龄），分别将MPC - 1304和尼卡地平以0.01%（0.01% MPC - 1304饮食）、0.03%（0.03% MPC - 1304饮食）和0.1%（0.1%尼卡地平饮食）的剂量添加到饮食中。长期摄入MPC - 1304和尼卡地平可抑制高血压的发展，并降低血清中血尿素氮、肌酐、甘油三酯和总胆固醇的浓度。MPC - 1304治疗可抑制脑中风、心脏纤维化、增生性和纤维样小动脉炎以及恶性肾硬化的发生率。0.01% MPC - 1304饮食和0.1%尼卡地平饮食的降压效果无显著差异。因此，MPC - 1304对易中风自发性高血压大鼠有降压作用。
