Nickels J L, Schneider W N, Dombovy M L, Wong T M
Department of Orthopedics, University of Rochester, Strong Memorial Hospital, NY 14642.
Brain Inj. 1994 Nov-Dec;8(8):709-18. doi: 10.3109/02699059409151025.
We retrospectively reviewed the charts of 12 subjects with brain injury who were treated with amantadine. Ten of the 12 subjects exhibited some improvement in cognitive and/or physical function while on amantadine. Areas most consistently showing improvement included focused and sustained attention and concentration, orientation, alertness, arousal, processing, time, and psychomotor speed, mobility, vocalization, agitation, anxiety and participation in therapy. Two of the three subjects with severe agitation showed dramatic resolution of the agitation. Eight of nine low-arousal subjects displayed an increased level of responsiveness. Areas with inconsistent response included memory, assaultiveness, and confusion. No response was seen in depression or sexual inappropriateness. Possible side-effects of amantadine were noted in five of the 12 subjects, and included pedal oedema, hypomania, generalized seizure, and visual hallucinations. This work suggests amantadine may play a role in neurobehavioural recovery of brain injury, and demonstrates the need for more in-depth study.
我们回顾性地查阅了12例接受金刚烷胺治疗的脑损伤患者的病历。12例患者中有10例在服用金刚烷胺期间认知和/或身体功能有一定改善。最常出现改善的方面包括集中持续注意力、定向力、警觉性、觉醒、处理能力、时间观念、精神运动速度、活动能力、发声、激动、焦虑以及参与治疗的情况。3例严重激动的患者中有2例激动症状显著缓解。9例低觉醒患者中有8例反应性增强。反应不一致的方面包括记忆、攻击性和意识模糊。在抑郁或行为不当方面未见疗效。12例患者中有5例出现了金刚烷胺可能的副作用，包括足部水肿、轻躁狂、全身性癫痫发作和视幻觉。这项研究表明金刚烷胺可能在脑损伤的神经行为恢复中发挥作用，并表明有必要进行更深入的研究。
