Backman U, Danielson B G, Sohtell M
Scand J Urol Nephrol. 1976;Suppl 35:76-90.
The urinary excretion of beta2-microglobulin was studied under normal conditions and during acidosis and alkalosis in 65 patients with renal stones. Eleven patients were studied under two of these conditions. Four out of 51 patients examined under normal conditions had an increased excretion of beta2-microglobulin in their urine. Four out of five patients with distal acidification defects were found to have an increased excretion of beta2-microglobulin during induced acidosis. During alkalosis, four out of eight patients with acidification defects increased their excretion of the protein. The tubular proteinuria that could be provoked during acute acidosis and alkalosis was considered to be secondary to changes in the acid-base status and may indicate a renal tubular defect.
对65例肾结石患者在正常情况下以及酸中毒和碱中毒期间的β2-微球蛋白尿排泄情况进行了研究。11例患者在其中两种情况下接受了研究。在正常情况下接受检查的51例患者中，有4例尿中β2-微球蛋白排泄增加。在诱发酸中毒期间，5例远端酸化缺陷患者中有4例被发现β2-微球蛋白排泄增加。在碱中毒期间，8例酸化缺陷患者中有4例蛋白质排泄增加。急性酸中毒和碱中毒期间可诱发的肾小管蛋白尿被认为是酸碱状态变化的继发结果，可能表明存在肾小管缺陷。
