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[在使用回转器的实验中,通过重力效应改变诱导蝾螈完全视网膜脱离后眼睛再生的特征]

[The characteristics of eye regeneration in newts after complete retinal detachment induced by a change in the effect of gravitation in an experiment using a clinostat].

作者信息

Grigorian E N, Anton H J

出版信息

Izv Akad Nauk Ser Biol. 1994 May-Jun(3):342-52.

PMID:7858463
Abstract

Morphological changes and proliferative activity of the neural retina cells after the neural retina detachment were studied in the newts subjected to microgravity in a clinostat. According to theoretical calculations, simulated microgravity could vary from 3.21 x 10(-2) to 8.05 x 10(-3) g. These conditions had a positive effect on morphological and functional restoration of the neural retina according to various criteria. Specifically, the increased number of Mullerian glial cells, increased relative volume of the plexiform layers, decreased mortality of the detached neural retina cells and increased redifferentiation of the retinal pigment epithelium and reattachment of the neural retina were observed. These changes were mainly found in the dorsal and central areas of the neural retina.

摘要

在回转器中对蝾螈进行微重力处理后,研究了神经视网膜脱离后神经视网膜细胞的形态变化和增殖活性。根据理论计算,模拟微重力可在3.21×10⁻²至8.05×10⁻³g之间变化。根据各种标准,这些条件对神经视网膜的形态和功能恢复有积极影响。具体而言,观察到米勒胶质细胞数量增加、神经纤维层相对体积增大、脱离的神经视网膜细胞死亡率降低、视网膜色素上皮细胞再分化增加以及神经视网膜重新附着。这些变化主要发生在神经视网膜的背侧和中央区域。

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