NS 1619对大鼠腹内侧下丘脑急性分离神经元中BKCa通道的激活作用。
Activation of BKCa channels in acutely dissociated neurones from the rat ventromedial hypothalamus by NS 1619.
作者信息
Sellers A J, Ashford M L
出版信息
Br J Pharmacol. 1994 Nov;113(3):659-61. doi: 10.1111/j.1476-5381.1994.tb17041.x.
Abstract
NS 1619 activates the large-conductance Ca(2+)-dependent K+ channel (BKCa) in membrane patches isolated from rat ventromedial hypothalamic neurones. The activation is concentration dependent, with a maximal effect at less than 30 microM, reversible and can be inhibited by application of iberiotoxin to the extracellular membrane. NS 1619 does not activate ATP-K+ channels present in the same neurones.
摘要
NS 1619可激活从大鼠下丘脑腹内侧神经元分离出的膜片中的大电导钙依赖性钾通道（BKCa）。这种激活呈浓度依赖性，在浓度低于30微摩尔时效果最佳，具有可逆性，且可通过向细胞外膜施加iberiotoxin来抑制。NS 1619不会激活同一神经元中存在的ATP钾通道。
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