采用超临界流体萃取法进行样品制备，对动物饲料中的药物进行定量分析。
Quantitative analysis of a drug in an animal feed employing sample preparation by supercritical fluid extraction.
作者信息
Messer D C, Taylor L T, Weiser W E, McRae J W, Cook C C
机构信息
Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg 24061.
出版信息
Pharm Res. 1994 Nov;11(11):1545-8. doi: 10.1023/a:1018993217413.
A pharmaceutical agent has been quantified in a rat feed matrix wherein sample preparation was achieved by supercritical fluid extraction. Spiking levels ranged from 0.0335% to 1.12%. Pure carbon dioxide, solid phase trapping on stainless steel with acetonitrile and liquid chromatographic assay yielded recoveries greater than 90% with relative standard deviations less than 5% in all cases except for the lowest spiking level. In this case recovery was 89.6% with an RSD of 9.6.
已对大鼠饲料基质中的一种药剂进行了定量分析，其中通过超临界流体萃取进行样品制备。加标水平范围为0.0335%至1.12%。纯二氧化碳、在不锈钢上用乙腈进行固相捕集以及液相色谱分析，除最低加标水平外，所有情况下回收率均大于90%，相对标准偏差小于5%。在这种情况下，回收率为89.6%，相对标准偏差为9.6%。
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