Yanagawa Y, Nakau H, Kita H, Shimizu A, Chigasaki H
Department of Neurosurgery, National Defence Medical College, Tokorozawa, Japan.
No To Shinkei. 1994 Nov;46(11):1069-74.
We present a case of Werner's syndrome associated with intracranial meningioma and a cerebrovascular disorder. A 49-year-old male was transferred to this hospital with a head injury as a result of a car accident, and a CT scan revealed a traumatic intracerebral hemorrhage. The patient displayed the characteristic clinical features of Werner's syndrome, including premature senility, juvenile cataract, atrophic skin, and a tendency to ward familial occurrence was present. MRI and cerebral angiography revealed multiple intracerebral hemorrhages, perhaps due to amyloid angiopathy, multiple lacunar infarctions and parasagittal meningioma. This is the first report on the MRI findings in the brain of a patient with Werner's syndrome. We suspect that of Werner's syndrome also shows evidence of premature aging on MR images.
我们报告一例与颅内脑膜瘤和脑血管疾病相关的沃纳综合征病例。一名49岁男性因车祸头部受伤被转诊至我院，CT扫描显示外伤性脑内出血。该患者表现出沃纳综合征的典型临床特征，包括早衰、青少年白内障、皮肤萎缩，且有家族发病倾向。MRI和脑血管造影显示多处脑内出血，可能由于淀粉样血管病所致，还有多处腔隙性梗死和矢状窦旁脑膜瘤。这是关于沃纳综合征患者脑部MRI表现的首例报告。我们怀疑沃纳综合征在MR图像上也显示出早衰的迹象。
