King R A, Segman R H, Anderson G M
Yale Child Study Center, Yale School of Medicine, New Haven, CT 06520-7900.
Isr J Psychiatry Relat Sci. 1994;31(4):271-9.
The general enhancement of central serotonin (5-HT) neurotransmission following long-term administration of serotonin-selective reuptake inhibitors (SSRIs) appears to play an important role in these drugs' anti-depressant efficacy. Because suicide and/or aggression appear linked to diminished levels of brain 5-HT and its metabolites, it has been suggested that SSRIs may be particularly effective in reducing suicidality. Case reports of increased or new suicidal ideation following administration of fluoxetine and other SSRIs, however, raise questions about how these potential side effects may relate to the SSRI's acute effects on 5-HT transmission. Part I of this review examines fluoxetine's effects on suicidality and related behaviors and reviews the relationship of suicidality to serotonergic dysregulation.
长期服用5-羟色胺选择性再摄取抑制剂（SSRI）后，中枢5-羟色胺（5-HT）神经传递的普遍增强似乎在这些药物的抗抑郁疗效中发挥着重要作用。由于自杀和/或攻击行为似乎与大脑5-HT及其代谢产物水平降低有关，有人提出SSRI可能在降低自杀倾向方面特别有效。然而，服用氟西汀和其他SSRI后出现增加或新的自杀意念的病例报告，引发了关于这些潜在副作用如何与SSRI对5-HT传递的急性影响相关的问题。本综述的第一部分研究了氟西汀对自杀倾向和相关行为的影响，并回顾了自杀倾向与血清素调节异常之间的关系。
