[转化淋巴细胞中的磷脂代谢。激活的分子机制]
[Phospholipid metabolism in transformed lymphocytes. Molecular mechanism of activation].
作者信息
Ferber E, Resch K
出版信息
Naturwissenschaften. 1976 Aug;63(8):375-81. doi: 10.1007/BF00607931.
PMID:787811
Abstract
An early consequence of lymphocyte stimulation by mitogens is the increased turnover of phospholipid fatty acid moieties. The enzymes catalyzing the selective transfer of fatty acids exhibit a high affinity for highly unsaturated fatty acids. The activation of these acyltransferases leads to a higher content of polyenoic fatty acids and consequently to an increased membrane fluidity.
摘要
丝裂原刺激淋巴细胞的早期结果是磷脂脂肪酸部分的周转率增加。催化脂肪酸选择性转移的酶对高度不饱和脂肪酸表现出高亲和力。这些酰基转移酶的激活导致多烯脂肪酸含量增加，从而使膜流动性增加。
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[Phospholipid metabolism in transformed lymphocytes. Molecular mechanism of activation].[转化淋巴细胞中的磷脂代谢。激活的分子机制]
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本文引用的文献
1
Isolation and characterization of lymphocyte plasma membranes.淋巴细胞质膜的分离与鉴定
Biochim Biophys Acta. 1972 May 9;266(2):494-504. doi: 10.1016/0005-2736(72)90105-8.
2
Phospholipid metabolism of stimulated lymphocytes: activation of acyl-CoA:lysolecithin acyltransferases in microsomal membranes.受刺激淋巴细胞的磷脂代谢：微粒体膜中酰基辅酶A：溶血卵磷脂酰基转移酶的激活
Biochim Biophys Acta. 1973 Feb 14;296(2):335-49. doi: 10.1016/0005-2760(73)90092-1.
3
Lymphocyte activation: rapid changes in the phospholipid metabolism of plasma membranes during stimulation.淋巴细胞活化：刺激过程中质膜磷脂代谢的快速变化。
Eur J Immunol. 1972 Dec;2(6):598-601. doi: 10.1002/eji.1830020623.
4
Phospholipid metabolism of stimulated lymphocytes. Effects of phytohemagglutinin, concanavalin A and anti-immunoglobulin serum.受刺激淋巴细胞的磷脂代谢。植物血凝素、伴刀豆球蛋白A及抗免疫球蛋白血清的作用。
Eur J Biochem. 1972 May;27(1):153-61. doi: 10.1111/j.1432-1033.1972.tb01821.x.
5
Phospholipid metabolism of stimulated lymphocytes. Composition of phospholipid fatty acids.受刺激淋巴细胞的磷脂代谢。磷脂脂肪酸的组成。
Biochim Biophys Acta. 1975 Sep 19;398(3):364-76. doi: 10.1016/0005-2760(75)90187-3.
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