Blumberg D L, Sklar C A, Wisoff J, David R
Department of Pediatrics, New York University Medical Center, NY 10016.
Childs Nerv Syst. 1994 Nov;10(8):505-8. doi: 10.1007/BF00335072.
We conducted a retrospective analysis of the cases of 122 children operated on for various brain tumors, to determine the incidence and natural history of postoperative diabetes insipidus (DI), and the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Abnormalities of water homeostasis were observed in 15 patients (12%). DI, with or without SIADH, was observed in 10 patients (8%), while SIADH alone was seen in five (4%). DI was permanent in five subjects (50%), whereas SIADH resolved completely in all affected individuals. Parenteral desmopressin (dDAVP) was an effective mode of therapy in the postoperative period. The effect did not correlate with a dosage strictly based on body weight.
我们对122例接受各种脑肿瘤手术的儿童病例进行了回顾性分析，以确定术后尿崩症（DI）和抗利尿激素分泌不当综合征（SIADH）的发生率及自然病程。15例患者（12%）出现了水稳态异常。10例患者（8%）出现了伴有或不伴有SIADH的DI，而仅5例（4%）出现了SIADH。5例患者（50%）的DI为永久性，而所有受影响个体的SIADH均完全缓解。术后肠外去氨加压素（dDAVP）是一种有效的治疗方式。其效果与严格基于体重的剂量无关。
