恶性胸腔积液淋巴细胞和LAK细胞对自体肿瘤细胞的细胞毒性研究。
A study of the cytotoxicity of malignant pleural effusion lymphocytes and LAK cells against autologous tumor cells.
作者信息
Guo Y S, Xing Z L
机构信息
First Affiliated Hospital of Lanzhou Medical College.
出版信息
Chin Med J (Engl). 1994 Dec;107(12):903-5.
The cytotoxicity of malignant pleural effusion lymphocytes (MPEL) against autologous tumor cells (ATC) were compared with that of peripheral blood lymphocytes (PBL). It was demonstrated that the cytotoxicity of PBL was higher than that of MPEL (P < 0.001), but the cytotoxicity and expansion of MPEL-activated by rIL-2 was much higher than that of PBL activated by rIL-2 (LAK cells) (P < 0.001). This shows that local immune reaction of the pleural cavity of patients with malignant pleural effusion was in the state of suppression. MPEL activated are better effector cells than LAK cells in tumor adoptive immunotherapy.
将恶性胸腔积液淋巴细胞（MPEL）对自体肿瘤细胞（ATC）的细胞毒性与外周血淋巴细胞（PBL）的细胞毒性进行了比较。结果表明，PBL的细胞毒性高于MPEL（P<0.001），但经重组白细胞介素-2（rIL-2）激活的MPEL的细胞毒性和扩增程度远高于经rIL-2激活的PBL（LAK细胞）（P<0.001）。这表明恶性胸腔积液患者胸腔局部免疫反应处于抑制状态。在肿瘤过继性免疫治疗中，激活的MPEL是比LAK细胞更好的效应细胞。
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