α-生育酚介导的铜（II）和高铁肌红蛋白诱导的人低密度脂蛋白氧化：脂质氢过氧化物的影响。

Alpha-tocopherol mediated peroxidation in the copper (II) and met myoglobin induced oxidation of human low density lipoprotein: the influence of lipid hydroperoxides.

作者信息

Iwatsuki M, Niki E, Stone D, Darley-Usmar V M

机构信息

Research Centre for Advanced Science and Technology, University of Tokyo, Japan.

出版信息

FEBS Lett. 1995 Mar 6;360(3):271-6. doi: 10.1016/0014-5793(95)00122-p.

DOI:10.1016/0014-5793(95)00122-p

PMID:7883046

Abstract

The principal antioxidant in human LDL, alpha-tocopherol, is converted to the alpha-tocopheroxyl radical after reaction with peroxyl radicals or Cu2+, and, if it does not terminate with peroxyl radicals, could initiate lipid peroxidation; a phenomenon called 'tocopherol mediated peroxidation'. Only in the presence of Cu2+ and low levels of lipid hydroperoxides was an alpha-tocopherol dependent decrease in the resistance of LDL to oxidation detected. This suggests that tocopherol mediated peroxidation will probably not contribute significantly as a pro-oxidant process in those individuals most at risk of developing atherosclerosis through an oxidative mechanism.

摘要

人类低密度脂蛋白（LDL）中的主要抗氧化剂α-生育酚，在与过氧自由基或Cu2+反应后会转化为α-生育酚自由基，如果它不与过氧自由基终止反应，就可能引发脂质过氧化；这种现象称为“生育酚介导的过氧化”。只有在Cu2+和低水平脂质氢过氧化物存在的情况下，才检测到α-生育酚依赖性地降低LDL对氧化的抵抗力。这表明，在那些最有可能通过氧化机制发展为动脉粥样硬化的个体中，生育酚介导的过氧化作为一种促氧化过程可能不会有显著作用。