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[不同类型诱变剂作用下人体细胞中维生素制剂抗诱变活性的差异]

[Differences in antimutagenic activity of vitamin preparations in human cells under the effect of various types of mutagens].

作者信息

Artamonova E Iu, Sinel'shchikova T A, Zasukhina G D

出版信息

Genetika. 1994 Nov;30(11):1556-7.

PMID:7883160
Abstract

The effect of ascorbic acid, retinol, and their mixture on the survival of human cells treated by mutagens was studied. The results provide evidence about the specific protective activity of each vitamin with respect to specific mutagenic effect. Information about specificity of "antimutagen-mutagen" effect accounting for mutagen cytotoxic properties can be readily obtained with the use of the method of vital cell staining with Tripane Blue.

摘要

研究了抗坏血酸、视黄醇及其混合物对经诱变剂处理的人类细胞存活的影响。结果提供了关于每种维生素针对特定诱变效应的特异性保护活性的证据。利用台盼蓝活细胞染色法可以很容易地获得关于考虑诱变剂细胞毒性特性的“抗诱变剂-诱变剂”效应特异性的信息。

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