Mohan G, Jain V K
Department of Pharmacology, S.N. Medical College, Agra.
Indian J Physiol Pharmacol. 1994 Oct;38(4):294-6.
In an attempt to find the prognostic value of serum magnesium in various complications, serum magnesium was estimated spectrophotometrically, in patients of acute myocardial infarction. There was a statistically insignificant difference in serum magnesium levels of complicated group of patients (1.627 +/- 0.192 mg/100 mL) and those who had uneventful recovery (1.412 +/- 0.132 mg/100 mL). However, this difference was highly significant when compared between control group (2.514 +/- 0.16 mg/100 mL) and complicated and uncomplicated cases separately. It was also observed that serum magnesium levels were lowest in patients who died due to major arrhythmias and cardiogenic shock followed by patients who had arrhythmias (especially ventricular tachycardia) and pump failure. The routine use of iv magnesium is recommended within first few hours of acute myocardial infarction to reduce mortality, arrhythmias and pump failure.
为了探寻血清镁在各种并发症中的预后价值，采用分光光度法对急性心肌梗死患者的血清镁进行了测定。并发症组患者的血清镁水平（1.627±0.192毫克/100毫升）与恢复顺利的患者（1.412±0.132毫克/100毫升）之间在统计学上无显著差异。然而，当分别将对照组（2.514±0.16毫克/100毫升）与并发症组及非并发症组进行比较时，这种差异具有高度显著性。还观察到，因严重心律失常和心源性休克死亡的患者血清镁水平最低，其次是发生心律失常（尤其是室性心动过速）和泵衰竭的患者。建议在急性心肌梗死的最初几小时内常规静脉使用镁，以降低死亡率、心律失常和泵衰竭的发生率。
