食管胸膜瘘：光动力治疗的一种并发症。

Esophagopleural fistula: a complication of photodynamic therapy.

作者信息

Temeck B K, Pass H I

机构信息

Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md 20892.

出版信息

South Med J. 1995 Mar;88(3):271-4.

PMID:7886521

Abstract

Mesothelioma of the pleura remains an incurable disease for which novel treatments are being investigated. One of these is intraoperative photodynamic therapy (PDT), using the principle of cell cytotoxicity produced by light-activated sensitization. We report a complication of this therapy that defined the maximal tolerated dose of PDT, ie, esophagopleural fistula, in two consecutive patients who had received the same dose of PDT at the time of extrapleural pneumonectomy.

摘要

胸膜间皮瘤仍然是一种无法治愈的疾病，目前正在研究新的治疗方法。其中一种是术中光动力疗法（PDT），它利用光激活致敏产生细胞毒性的原理。我们报告了这种疗法的一种并发症，即食管胸膜瘘，它确定了PDT的最大耐受剂量。在两名连续接受相同剂量PDT的患者中，该并发症发生在胸膜外全肺切除术时。